Product Description
CAYMAN CHEMICAL 22378-1 - METHOTREXATE-D3 - METHOTREXATE-D3 IS INTENDED FOR USE AS AN INTERNAL STANDARD FOR THE QUANTIFICATION OF MTX (ITEM NO. 13960) BY GC- OR LC-MS. MTX IS SIMILAR IN STRUCTURE TO FOLIC ACID (ITEM NO. 20515) AND AMINOPTERIN (ITEM NO. 21802). IT ACTS BY INHIBITING THE METABOLISM OF FOLIC ACID AND BLOCKING KEY ENZYMES IN THE SYNTHESIS OF PURINES AND PYRIMIDINES REQUIRED FOR CELL PROLIFERATION.21827,21826 MTX IS KNOWN TO INDUCE ADENOSINE RELEASE, WHICH MEDIATES MANY OF ITS ANTI-INFLAMMATORY EFFECTS, INCLUDING THE REDUCTION OF PROINFLAMMATORY CYTOKINES.21826,21828,21830 FORMULATIONS CONTAINING MTX HAVE BEEN USED IN THE TR - EQUAL TO CHM11U039-EA
MANUFACTURER:
CAYMAN CHEMICAL
MANUFACTURER PART NUMBER:
22378-1
UNIT OF MEASURE:
EA
QTY PER UNIT OF MEASURE:
1
COUNTRY OF ORIGIN:
ORDER INCREMENT:
1
WEIGHT:
0
CONTRACTOR PART NUMBER:
2800051586
