Product Description
MILLIPORE SIGMA SMB00932-50MG - 2-DEOXY-D-GLUCOSE 6-PHOSPHATE SODIUM SALT >=98% (HPLC) - 2-DEOXY-D-GLUCOSE (2DG) IS A GLUCOSE MOLECULE WHICH HAS THE 2-HYDROXYL GROUP REPLACED BY HYDROGEN, SO THAT IT CANNOT UNDERGO FURTHER GLYCOLYSIS. AS SUCH, IT ACTS TO COMPETITIVELY INHIBIT THE PRODUCTION OF GLUCOSE-6-PHOSPHATE FROM GLUCOSE AT THE PHOSPHOGLUCOISOMERASE LEVEL (STEP 2 OF GLYCOLYSIS). IN MOST CELLS, GLUCOSE HEXOKINASE PHOSPHORYLATES 2-DEOXYGLUCOSE, TRAPPING THE PRODUCT 2-DEOXYGLUCOSE-6-PHOSPHATE (2DG6P) INTRACELLULARLY. 2DG & 2DG6P SERVE AS GOOD MARKERS FOR TISSUE GLUCOSE UPTAKE AND HEXOKINASE ACTIVITY. FOR EXAMPLE, MANY CANCERS HAVE ELEVATED GLUCOSE UPTAKE AND HEXOKINASE LEVELS. 2D - EQUAL TO CHM02G307-EA
MANUFACTURER:
MILLIPORE SIGMA
MANUFACTURER PART NUMBER:
SMB00932-50MG
UNIT OF MEASURE:
EA
QTY PER UNIT OF MEASURE:
1
COUNTRY OF ORIGIN:
ORDER INCREMENT:
1
WEIGHT:
0
CONTRACTOR PART NUMBER:
2800292318
